Description

2-Isobutoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine is a high-value, organoboron building block essential for modern synthetic chemistry. This compound is specifically designed for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly in the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing trifluoromethylpyridine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides that require specific pyridine-boronic ester derivatives.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or components for conductive polymers.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to form carbon-carbon bonds, facilitating the synthesis of biaryl and heterobiaryl structures.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through parallel and combinatorial synthesis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Item	Details
Product Name	2-Isobutoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine
CAS No.	1256359-93-9
Molecular Formula	C16H23BF3NO3
Molecular Weight	345.17 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)-3-isobutoxypyridine; 3-Isobutoxy-5-(trifluoromethyl)pyridine-2-boronic acid pinacol ester; 2-Isobutoxy-5-(trifluoromethyl)-3-pyridineboronic acid pinacol ester; 5-(Trifluoromethyl)-3-isobutoxy-2-pyridineboronic acid pinacol ester; Pinacol [3-isobutoxy-5-(trifluoromethyl)pyridin-2-yl]boronate; Boronic acid, B-[3-[(2-methylpropyl)oxy]-5-(trifluoromethyl)-2-pyridinyl]-, pinacol ester; CAS 1256359-93-9
EINECS	Contact for details

Quality Control

Every batch of our 2-Isobutoxy-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethyl)pyridine is produced and analyzed under strict quality management systems. We guarantee high purity and batch-to-batch consistency through advanced analytical techniques including NMR, HPLC, and GC-MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to moisture. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.