Description

2-(5-Methoxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Acetonitrile is a high-purity, advanced pharmaceutical intermediate featuring a versatile boronic ester pinacol protecting group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic chemistry for constructing complex molecules. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds between aryl/heteroaryl halides and the boronic ester moiety, essential for constructing biaryl structures in drug discovery.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Serves as a monomer or precursor for developing organic electronic materials, such as polymers for OLEDs (Organic Light-Emitting Diodes) and OFETs (Organic Field-Effect Transistors).
• Ligand and Catalyst Development: Acts as a precursor for creating sophisticated ligands and organometallic catalysts used in asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and protein functions.

Basic Information

Product Name	2-(5-Methoxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Acetonitrile
CAS No.	1256359-92-8
Molecular Formula	C₁₇H₂₂BNO₄
Molecular Weight	315.17 g/mol
Synonyms	(5-Methoxy-2-(2-cyanoethoxy)phenyl)boronic acid pinacol ester; 2-[5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]acetonitrile; 2-(5-Methoxy-2-(pinacolatoboryl)phenoxy)acetonitrile; 2-(5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanenitrile; Boronic acid, B-[2-(2-cyanoethoxy)-4-methoxyphenyl]-, pinacol ester; CAS 1256359-92-8
EINECS	Contact for details

Quality Control

Every batch of 2-(5-Methoxy-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenoxy)Acetonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are developed to meet the stringent requirements of cGMP and ICH guidelines for advanced pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation (by NMR and IR), and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to maintain stability and prevent moisture absorption. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.