Description

1-Boc-6-Methylindole-3-Boronic Acid, Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the development of novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those containing functionalized indole scaffolds.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron-containing reagent for palladium-catalyzed coupling reactions to form biaryl and heterobiaryl structures.
• Agrochemical Research: Used in the development of new active ingredients for crop protection products.
• Material Science: Employed in the synthesis of organic semiconductors, ligands, and advanced polymers.
• Chemical Biology & Medicinal Chemistry: Facilitates the creation of molecular probes and libraries for high-throughput screening and structure-activity relationship (SAR) studies.
• Process Chemistry & Scale-up: Suitable for use in route development and optimization for commercial-scale manufacturing.

Basic Information

Product Name	1-Boc-6-Methylindole-3-Boronic Acid, Pinacol Ester
CAS No.	1256359-86-0
Molecular Formula	C20H28BNO4
Molecular Weight	357.26 g/mol
Synonyms	1-Boc-6-Methyl-1H-indole-3-boronic acid pinacol ester; 6-Methyl-1-[(tert-butoxy)carbonyl]-1H-indole-3-boronic acid pinacol ester; tert-Butyl 6-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-1-carboxylate; 1-Boc-6-methylindole-3-boronic acid pinacol ester; 1-(tert-Butoxycarbonyl)-6-methylindole-3-boronic acid pinacol ester; 6-Methyl-1-Boc-indole-3-boronic acid pinacol ester; Boronic acid, B-[1-[(1,1-dimethylethoxy)carbonyl]-6-methyl-1H-indol-3-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Methylindole-3-Boronic Acid, Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is analyzed using advanced techniques including NMR and HPLC to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep container tightly sealed in a desiccated environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.