Description

n-tert-Butyl-2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)acetamide is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science sectors, facilitating the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing biaryl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in constructing complex molecules for novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Materials Science Research: Building block for creating organic electronic materials, such as polymers for OLEDs or organic photovoltaics, where precise molecular architecture is crucial.
• Chemical Biology & Probe Development: Enables the labeling and modification of biomolecules or the creation of molecular probes for diagnostic applications.
• Academic & R&D Laboratories: A versatile reagent for methodological development and the synthesis of complex natural product analogs or novel chemical entities.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale synthesis due to its stability and predictable reactivity in cross-coupling reactions.

Basic Information

Product Name	n-tert-Butyl-2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)acetamide
CAS No.	1256359-83-7
Molecular Formula	C18H28BNO3
Molecular Weight	317.24 g/mol
Synonyms	4-(2-((tert-Butylamino)-2-oxoethyl)phenylboronic acid pinacol ester; 2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-N-(tert-butyl)acetamide; N-tert-Butyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 4-(N-tert-Butylcarbamoylmethyl)phenylboronic acid pinacol ester; B-[4-[2-[(1,1-Dimethylethyl)amino]-2-oxoethyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our n-tert-Butyl-2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)phenyl)acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.