Description

n-Methyl-2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group, which is critical for modern synthetic methodologies. This compound is engineered to serve as a key building block in the synthesis of complex molecules, offering precise reactivity for cross-coupling reactions. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A crucial precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl structures found in novel drug candidates.
• Agrochemical Research: Used in the synthesis of advanced herbicides and fungicides that require specific boronic ester functionalities.
• Material Science: Serves as a monomer or functionalizing agent in the development of organic electronic materials and polymers.
• Chemical Biology: Employed as a probe or linker in bioconjugation and proteomics research due to its selective reactivity.
• Catalyst Ligand Synthesis: Acts as a starting material for creating sophisticated ligand systems used in homogeneous catalysis.
• Custom Synthesis: Provides a versatile handle for contract research organizations (CROs) and CDMOs performing bespoke synthetic routes for clients.

Basic Information

Product Name	n-Methyl-2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide
CAS No.	1256359-34-8
Molecular Formula	C15H22BNO3
Molecular Weight	275.15 g/mol
Synonyms	2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-N-methylacetamide; 4-(N-Methylacetamidomethyl)phenylboronic acid pinacol ester; N-Methyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 4-(2-(Methylamino)-2-oxoethyl)phenylboronic acid pinacol ester; Boronic acid, B-[4-[(methylamino)carbonyl]methyl]phenyl]-, 1,1-dimethylethyl ester (9CI); CAS 1256359-34-8; Pinacol [4-(N-Methylcarbamoylmethyl)phenyl]boronate
EINECS	Contact for details

Quality Control

Our production of n-Methyl-2-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Acetamide adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive cross-coupling applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We operate under a cGMP-compliant quality management system, and our analytical methods are validated to meet the exacting standards of the pharmaceutical and fine chemical industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.