Description

2-(2,6-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenoxy)Acetonitrile is a high-value, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critical for enabling efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry. It is primarily sought after by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active compounds and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly for small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for constructing biaryl and heterobiaryl structures, which are common motifs in many drugs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides, herbicides, and fungicides requiring specific aromatic architectures.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs and organic photovoltaics, where precise molecular structure is paramount.
• Chemical Biology Probes: Utilized in the development of molecular probes and labeled compounds for diagnostic and research applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Item	Detail
Product Name	2-(2,6-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenoxy)Acetonitrile
CAS No.	1256359-33-7
Molecular Formula	C18H26BNO3
Molecular Weight	315.22 g/mol
Synonyms	4-(2-Cyanoethoxy)-3,5-dimethylphenylboronic acid pinacol ester; 2-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,6-dimethylphenoxy]acetonitrile; 2,6-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxyacetonitrile; (4-(2-Cyanoethoxy)-3,5-dimethylphenyl)boronic acid pinacol ester; PINACOL [4-(2-CYANOETHOXY)-3,5-DIMETHYLPHENYL]BORONATE
EINECS	Contact for details

Quality Control

Every batch of 2-(2,6-Dimethyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenoxy)Acetonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.