Description

2-Isopropoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine is a high-value, multi-functional boronic ester derivative, primarily utilized as a critical synthetic intermediate in advanced organic synthesis. Its core value proposition lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who are developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl-substituted pyridine cores, which are prevalent in modern drug discovery for their metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the pyridine-boronate moiety facilitates the creation of complex, bioactive molecules.
• Material Science & OLED Development: Serves as a precursor for constructing organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or monomers for conjugated polymers used in organic light-emitting diodes (OLEDs).
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugation reagents, leveraging the selective reactivity of the boronic ester group.
• Cross-Coupling Reactions: Primarily designed for use in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-isopropoxy-6-(trifluoromethyl)pyridin-4-yl fragment into target molecules with high efficiency.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the fine chemical and life science sectors.

Basic Information

Product Name	2-Isopropoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine
CAS No.	1256359-31-5
Molecular Formula	C15H21BF3NO3
Molecular Weight	331.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-isopropoxy-6-(trifluoromethyl)pyridine; 2-Isopropoxy-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester; 6-(Trifluoromethyl)-2-isopropoxypyridine-4-boronic acid pinacol ester; 4-Borono-2-isopropoxy-6-(trifluoromethyl)pyridine pinacol ester; Pyridine, 2-isopropoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-; (2-Isopropoxy-6-(trifluoromethyl)pyridin-4-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 2-Isopropoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization, including HPLC for purity assessment, NMR (1H, 13C, 19F, 11B) for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.