Description

2-Ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine is a high-value, multi-functional boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in enabling efficient cross-coupling reactions, which are fundamental for constructing complex molecular architectures with precision. This compound is primarily needed by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those containing trifluoromethylpyridine motifs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic structures.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or charge-transport materials, where the boronic ester group facilitates polymerization or functionalization.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes, leveraging its reactivity for bioconjugation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional laboratories for methodological development in organoboron chemistry and catalysis studies.

Basic Information

Product Name	2-Ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine
CAS No.	1256359-30-4
Molecular Formula	C14H19BF3NO3
Molecular Weight	317.11 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-ethoxy-6-(trifluoromethyl)pyridine; 2-Ethoxy-6-(trifluoromethyl)pyridine-4-boronic acid pinacol ester; 6-(Trifluoromethyl)-2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-Pinacolatoboryl-2-ethoxy-6-trifluoromethylpyridine; 2-Ethoxy-4-(pinacolatoboryl)-6-(trifluoromethyl)pyridine; Pyridine, 2-ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Ethoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-6-(trifluoromethyl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR (1H, 13C, 19F, 11B), and GC/MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is between 2°C and 8°C for long-term stability. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.