Description

Benzyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropylcarbamate is a high-purity, advanced pharmaceutical intermediate featuring a protected boronic ester functional group. This compound is critically important as a key building block in modern synthetic chemistry, particularly for the construction of complex molecules via cross-coupling reactions. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a crucial boronic ester reagent for forming carbon-carbon bonds in the synthesis of complex biaryl and heterobiaryl structures.
• Pharmaceutical Intermediate: A key precursor in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced active ingredients for crop protection products.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and semiconductors.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes.
• Process Chemistry & Scale-Up: Provides a stable, storable form of a reactive aryl boronic acid for efficient large-scale manufacturing.

Basic Information

Product Name	Benzyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropylcarbamate
CAS No.	1256359-24-6
Molecular Formula	C23H28BNO4
Molecular Weight	393.29 g/mol
Synonyms	Benzyl N-[1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropyl]carbamate; 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)cyclopropanaminium Benzyl Carbonate; Benzyl (1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Phenyl)Cyclopropyl)Carbamate; BOC-Protected Aryl Boronic Ester Intermediate; Pinacol Boronate Ester Derivative
EINECS	Contact for details

Quality Control

Our Benzyl 1-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Cyclopropylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to prevent oxidation and ensure long-term stability. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.