Description

4-Cyanoindole-2-Boronic Acid Pinacol Ester is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This advanced intermediate is critically needed by pharmaceutical, agrochemical, and advanced materials researchers for the development of novel indole-based compounds, including active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators with indole scaffolds.
• Material Science: Serves as a precursor for creating organic electronic materials, such as OLED emitters and charge-transport layers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Cross-Coupling Reactions: A pivotal reagent in palladium-catalyzed Suzuki-Miyaura cross-coupling for biaryl and heterobiaryl synthesis.
• Library Synthesis: Enables rapid parallel and combinatorial synthesis for high-throughput screening in drug discovery programs.

Basic Information

Product Name	4-Cyanoindole-2-Boronic Acid Pinacol Ester
CAS No.	1256359-19-9
Molecular Formula	C₁₅H₁₇BN₂O₂
Molecular Weight	268.12 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-4-carbonitrile; 4-Cyano-1H-indole-2-boronic acid pinacol ester; 4-Cyanoindole-2-boronic acid pinacol ester; 1H-Indole-4-carbonitrile, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 4-CN-Indole-2-Bpin; 2-Bpin-4-cyanoindole
EINECS	Contact for details

Quality Control

Our 4-Cyanoindole-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.