Description

5-Cyanoindole-2-Boronic Acid, Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry, specifically designed for Suzuki-Miyaura cross-coupling reactions. Its core value lies in enabling the efficient and selective construction of complex indole-based heterocycles, which are privileged scaffolds in medicinal chemistry. This compound is essential for researchers and process chemists in pharmaceutical R&D and fine chemical synthesis who require reliable, high-purity intermediates for developing new active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel indole-containing drug candidates, including kinase inhibitors and receptor modulators.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester partner for palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides.
• Agrochemical Research: Used in the development of new herbicides and fungicides with indole-based structures.
• Material Science: Employed in the creation of organic electronic materials and advanced polymers requiring specific indole motifs.
• Chemical Biology & Probe Development: Facilitates the synthesis of labeled compounds and molecular probes for biological target identification and study.

Basic Information

Product Name	5-Cyanoindole-2-Boronic Acid, Pinacol Ester
CAS No.	1256359-11-1
Molecular Formula	C15H17BN2O2
Molecular Weight	268.12 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-5-carbonitrile; 5-Cyano-1H-indole-2-boronic acid pinacol ester; 5-Cyanoindole-2-boronic acid pinacol ester; 1H-Indole-5-carbonitrile, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-CN-Indole-2-Bpin
EINECS	Contact for details

Quality Control

Our 5-Cyanoindole-2-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation and moisture absorption. Allow the sealed container to reach room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.