Description

1H-Indazole, 1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-purity, advanced pharmaceutical intermediate featuring a valuable boronic ester functional group. This compound matters as a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients. Its specific structure makes it essential for constructing indazole-based scaffolds with high precision.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester moiety enables efficient carbon-carbon bond formation, a cornerstone of modern drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides with novel modes of action.
• Material Science Exploration: Serves as a building block for organic electronic materials and functional polymers.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Utilized in the design of bifunctional molecules for targeted protein degradation.
• Contract Research & Development (CRO/CDMO): Supplied to service organizations for client-directed synthetic projects requiring specialized boronic acid derivatives.

Basic Information

Product Name	1H-Indazole, 1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1256359-09-7
Molecular Formula	C₁₄H₁₉BN₂O₂
Molecular Weight	258.13 g/mol
Synonyms	1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1H-indazole; 1-Methyl-1H-indazole-6-boronic acid pinacol ester; 1-Methyl-6-(pinacolboryl)-1H-indazole; 6-(Pinacolatoboryl)-1-methyl-1H-indazole; 1-Methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazole; 1256359-09-7
EINECS	Contact for details

Quality Control

Our 1H-Indazole, 1-Methyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation and maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.