Description

2-[2-(2-Chloroethoxy)Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-value organoboron building block, specifically a pinacol boronic ester derivative. This compound is critical for enabling advanced cross-coupling reactions, such as the Suzuki-Miyaura coupling, which are fundamental to modern synthetic chemistry. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing biaryl and heterobiaryl structures common in drug molecules.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including polymers for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CROs/CMOs serving the life sciences industry.

Basic Information

Product Name	2-[2-(2-Chloroethoxy)Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	1256359-02-0
Molecular Formula	C14H20BClO3
Molecular Weight	282.57 g/mol
Synonyms	2-(2-(2-Chloroethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-(2-Chloroethoxy)phenyl)boronic acid pinacol ester; 1-Chloro-2-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethane; 2-(2-Chloroethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [2-(2-chloroethoxy)phenyl]boronate; Boronic acid, B-[2-(2-chloroethoxy)phenyl]-, 1,1-dimethylethyl ester; 2-(2-(2-Chloroethoxy)phenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane
EINECS	Contact for details

Quality Control

Our production of 2-[2-(2-Chloroethoxy)Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including NMR, HPLC, and GC analysis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.