Description

4-(2-Chloro-Ethoxy)-Phenyl-4,4,5,5-Tetramethyl-1,3,2Dioxaborolane is a high-purity boronic ester derivative, a crucial building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for forming carbon-carbon bonds in complex molecule assembly. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing new active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and CNS drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science: Serves as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of bioconjugates and molecular probes for diagnostic and research applications.
• Custom Synthesis and R&D: A versatile reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic pathways.

Basic Information

Product Name	4-(2-Chloro-Ethoxy)-Phenyl-4,4,5,5-Tetramethyl-1,3,2Dioxaborolane
CAS No.	1256359-01-9
Molecular Formula	C16H24BClO3
Molecular Weight	310.62 g/mol
Synonyms	4-(2-Chloroethoxy)phenylboronic acid pinacol ester; 2-[4-(2-Chloroethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 1-Chloro-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethane; 4-(2-Chloroethoxy)benzeneboronic acid pinacol ester; Pinacol [4-(2-chloroethoxy)phenyl]boronate; CAS 1256359-01-9
EINECS	Contact for details

Quality Control

Our 4-(2-Chloro-Ethoxy)-Phenyl-4,4,5,5-Tetramethyl-1,3,2Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistent performance in sensitive cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.