Description

4-Bromo-1H-Indole-2-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative crucial for modern synthetic organic chemistry. This compound serves as a key synthetic intermediate, enabling the construction of complex indole-based molecular architectures through versatile cross-coupling reactions. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for the development of new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel indole-containing drug candidates, particularly for oncology and CNS disorders.
• Suzuki-Miyaura Cross-Coupling Reactions: Enables the formation of carbon-carbon bonds to introduce the 4-bromoindole moiety into complex molecules with high efficiency and selectivity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that leverage the indole scaffold.
• Material Science: Employed in the synthesis of organic semiconductors, ligands for catalysis, and advanced polymers.
• Academic & Contract Research: Essential reagent for medicinal chemistry programs and methodological studies in university and CRO laboratories.
• Scale-up Synthesis: Supplied in development and commercial quantities for process chemistry and GMP manufacturing campaigns.

Basic Information

Product Name	4-Bromo-1H-Indole-2-Boronic Acid Pinacol Ester
CAS No.	1256358-97-0
Molecular Formula	C₁₄H₁₇BBrNO₂
Molecular Weight	322.01 g/mol
Synonyms	4-Bromo-1H-indole-2-boronic acid pinacol ester; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-bromo-1H-indole; 4-Bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 4-Bromoindole-2-boronic acid pinacol ester; 4-Bromo-1H-indol-2-ylboronic acid pinacol ester; B-(4-Bromo-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of 4-Bromo-1H-Indole-2-Boronic Acid Pinacol Ester is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency essential for sensitive cross-coupling reactions. Certificates of Analysis (COA) with full analytical data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain optimal purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.