Description

5-Fluoro-1H-Indole-2-Boronic Acid Pinacol Ester is a high-value, protected boronic acid derivative essential for modern synthetic chemistry, particularly in cross-coupling reactions. This compound serves as a critical building block for constructing complex molecular architectures with precision and efficiency. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel indole-based compounds.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators that incorporate the 5-fluoroindole scaffold.
• Material Science: Employed in the creation of organic semiconductors, liquid crystals, and functional polymers requiring specific electronic properties.
• Chemical Biology & Probe Development: Utilized to create fluorescent probes or affinity tags for studying biological processes and protein interactions.
• Academic & Contract Research: Serves as a versatile reagent in university laboratories and CROs (Contract Research Organizations) for methodological development and library synthesis.
• Scale-up & Process Chemistry: Suitable for process optimization and pilot-scale synthesis of target molecules due to the stability imparted by the pinacol ester protecting group.

Basic Information

Product Name	5-Fluoro-1H-Indole-2-Boronic Acid Pinacol Ester
CAS No.	1256358-94-7
Molecular Formula	C₁₄H₁₇BFNO₂
Molecular Weight	261.10 g/mol
Synonyms	5-Fluoro-1H-indole-2-boronic acid pinacol ester; 2-(5-Fluoro-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Fluoroindole-2-boronic acid pinacol ester; 5-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 5-Fluoro-1H-indole-2-boronpinacol ester; 5-Fluoro-2-indoleboronic acid pinacol ester; 5-Fluoro-2-boronpinacol-1H-indole.
EINECS	Contact for details

Quality Control

Our 5-Fluoro-1H-Indole-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance in sensitive applications like pharmaceutical synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.