Description

5-Methylindole-2-Boronic Acid Pinacol Ester is a high-purity, protected boronic acid derivative essential for modern synthetic chemistry. This compound serves as a critical building block in cross-coupling reactions, enabling the efficient construction of complex heterocyclic scaffolds. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers for developing novel active pharmaceutical ingredients (APIs) and advanced materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds in the synthesis of complex indole derivatives and other heterocycles.
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those targeting neurological and oncological pathways.
• Agrochemical Synthesis: Employed in creating novel, high-performance crop protection agents and herbicides.
• Material Science Research: Acts as a precursor for organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology Probes: Useful for labeling and studying biological systems due to its reactive boronate functionality.
• Catalyst and Ligand Development: Serves as a starting material for synthesizing specialized catalysts and ligands used in asymmetric synthesis.

Basic Information

Product Name	5-Methylindole-2-Boronic Acid Pinacol Ester
CAS No.	1256358-93-6
Molecular Formula	C15H20BNO2
Molecular Weight	257.14 g/mol
Synonyms	5-Methyl-1H-indole-2-boronic acid pinacol ester; 2-(5-Methyl-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Methylindole-2-boronic acid, pinacol ester; 5-Methyl-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 5-Methyl-1H-indole-2-boronic acid, cyclic ester with pinacol; Boronic acid, B-(5-methyl-1H-indol-2-yl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 5-Methylindole-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. We adhere to cGMP principles for pharmaceutical-grade intermediates, ensuring traceability and compliance with global regulatory expectations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term stability to prevent potential degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.