Description

5-Bromoindole-2-Boronic Acid, Pinacol Ester is a high-value, protected boronic acid derivative crucial for modern synthetic organic chemistry. Its primary value lies in enabling efficient, palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura reaction, to construct complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key building block for developing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing indole-based drug candidates, including kinase inhibitors, serotonin receptor modulators, and other bioactive molecules.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators with complex heterocyclic structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge-transport layers, due to the indole core.
• Chemical Biology & Proteomics: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Academic & R&D Laboratories: A fundamental reagent for methodological development in cross-coupling chemistry and the exploration of new synthetic pathways.
• Scale-up Process Chemistry: Suitable for transition from laboratory-scale discovery to pilot and commercial-scale manufacturing of fine chemicals.

Basic Information

Product Name	5-Bromoindole-2-Boronic Acid, Pinacol Ester
CAS No.	1256358-92-5
Molecular Formula	C14H17BBrNO2
Molecular Weight	322.01 g/mol
Synonyms	5-Bromo-1H-indole-2-boronic acid pinacol ester; 2-(5-Bromo-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Bromoindole-2-boronic acid pinacol cyclic ester; 5-Bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; 5-Bromo-2-indolylboronic acid pinacol ester; Pinacol 5-bromoindole-2-boronate; 5-Br-indole-2-Bpin
EINECS	Contact for details

Quality Control

Our 5-Bromoindole-2-Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our commitment to quality supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.