Description

5-Chloroindole-2-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable organoboron building block. This compound is essential for modern cross-coupling reactions, enabling the efficient construction of complex indole-based molecular architectures. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used to create advanced indole-derived compounds with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology: Employed in the synthesis of molecular probes and labeled compounds for studying biological pathways and protein interactions.
• Catalyst Ligand Synthesis: Acts as a building block for creating sophisticated ligand systems used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke organic molecules for clients.

Basic Information

Product Name	5-Chloroindole-2-Boronic Acid Pinacol Ester
CAS No.	1256358-91-4
Molecular Formula	C14H17BClNO2
Molecular Weight	277.55 g/mol
Synonyms	5-Chloro-1H-indole-2-boronic acid pinacol ester; 2-(5-Chloro-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 5-Chloroindole-2-boronic acid pinacol ester; 5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole; B-(5-Chloro-1H-indol-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 5-Chloroindole-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity. We provide detailed Certificates of Analysis (COA) with every shipment, confirming compliance with your specified requirements and industry standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent hydrolysis of the boronic ester moiety. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.