Description

3-Methoxypyridine-2-Boronic Acid, Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, essential for modern cross-coupling chemistry. Its primary value lies in serving as a stable, air- and moisture-handleable precursor to the corresponding boronic acid, a key building block in Suzuki-Miyaura reactions. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex heterocyclic scaffolds. Its pinacol ester protection offers enhanced stability for storage and shipping compared to the free acid form.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing functionalized pyridine or bipyridine motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides that require specific heterocyclic structures.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Suzuki-Miyaura Cross-Coupling: Acts as a stable organoboron reagent for forming carbon-carbon bonds between pyridine rings and various aryl or vinyl halides, a cornerstone reaction in medicinal and process chemistry.
• Chemical Biology & Probe Development: Useful for creating molecular probes and bioconjugates where the pyridine moiety serves as a coordinating or targeting element.
• Catalyst Ligand Preparation: Serves as a precursor for synthesizing novel bidentate or polydentate nitrogen-based ligands for transition metal catalysis.

Basic Information

Product Name	3-Methoxypyridine-2-Boronic Acid, Pinacol Ester
CAS No.	1256358-87-8
Molecular Formula	C12H18BNO3
Molecular Weight	235.09 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methoxypyridine; 3-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Methoxypyridine-2-boronic acid pinacol ester; 2-(3-Methoxypyridin-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (3-Methoxypyridin-2-yl)boronate
EINECS	Contact for details

Quality Control

Every batch of 3-Methoxypyridine-2-Boronic Acid, Pinacol Ester is produced and tested under strict quality management protocols to ensure consistency and reliability for sensitive synthetic applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with exacting industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.