Description

2-(Pyridin-2-Ylmethoxy)Phenylboronic Acid is a specialized organoboron compound featuring a pyridine-methoxy linker, making it a valuable bifunctional building block in synthetic chemistry. Its primary value lies in its dual reactivity, where the boronic acid group participates in Suzuki-Miyaura cross-coupling reactions, while the pyridine moiety can act as a ligand or a directing group. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in materials science for creating advanced organic frameworks.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders or serving as kinase inhibitors.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand in Catalysis: The pyridine nitrogen can coordinate to metal centers, making it useful in designing novel catalysts for asymmetric synthesis and other transition metal-catalyzed reactions.
• Material Science Building Block: Employed in the construction of Metal-Organic Frameworks (MOFs), covalent organic frameworks (COFs), and organic electronic materials.
• Chemical Biology Probe: Serves as a versatile handle for bioconjugation and the development of chemical probes to study biological processes.
• Cross-Coupling Reactions: Primarily utilized in Suzuki-Miyaura cross-coupling to form biaryl and heterobiaryl structures, which are core scaffolds in many functional molecules.

Basic Information

Product Name	2-(Pyridin-2-Ylmethoxy)Phenylboronic Acid
CAS No.	1256355-48-2
Molecular Formula	C₁₂H₁₂BNO₃
Molecular Weight	229.04 g/mol
Synonyms	[2-(2-Pyridinylmethoxy)phenyl]boronic acid; 2-(Pyridin-2-ylmethoxy)benzeneboronic acid; 2-(2-Pyridylmethoxy)phenylboronic Acid; (2-((Pyridin-2-yl)methoxy)phenyl)boronic acid; B-[2-[(Pyridin-2-yl)methoxy]phenyl]boronic acid
EINECS	Contact for details

Quality Control

Our 2-(Pyridin-2-Ylmethoxy)Phenylboronic Acid is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.