Description

4'-Chloro-3',5'-Difluoroacetophenone is a high-purity fluorinated and chlorinated acetophenone derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique halogenated aromatic structure makes it an indispensable building block for constructing complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for molecules requiring a difluorinated and chlorinated phenyl ketone moiety.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the halogen atoms contribute to biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs or semiconductors, where fluorinated aromatics are valued for their electronic properties.
• Custom Chemical Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs engaged in custom synthesis and scale-up projects.

Basic Information

Product Name	4'-Chloro-3',5'-Difluoroacetophenone
CAS No.	1256352-85-8
Molecular Formula	C8H5ClF2O
Molecular Weight	190.57 g/mol
Synonyms	1-(4-Chloro-3,5-difluorophenyl)ethanone; 4-Chloro-3,5-difluoroacetophenone; 3',5'-Difluoro-4'-chloroacetophenone; 4-Chloro-3,5-difluoroacetophenone; 1-(4-Chloro-3,5-difluorophenyl)ethan-1-one; Acetophenone, 4'-chloro-3',5'-difluoro-
EINECS	Contact for details

Quality Control

Every batch of 4'-Chloro-3',5'-Difluoroacetophenone is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.