Description

(2S)-2-Amino-3,3,3-trifluoropropan-1-ol hydrochloride is a high-purity chiral building block and pharmaceutical intermediate of significant commercial interest. This compound is valued for its trifluoromethyl group, which is a key structural motif known to enhance the metabolic stability, lipophilicity, and bioavailability of active pharmaceutical ingredients. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel fluorinated compounds, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in oncology, CNS, and metabolic disease research.
• Agrochemical Synthesis: Used in the development of advanced fluorinated pesticides and herbicides, where the CF3 group can improve efficacy and environmental profile.
• Organofluorine Chemistry Research: Serves as a versatile starting material in academic and industrial R&D for exploring new reactions and methodologies involving fluorinated amino alcohols.
• Peptidomimetics & Bioactive Molecules: Incorporated into the backbone of peptide analogs and other bioactive molecules to modulate their physicochemical properties and receptor binding.
• Ligand & Catalyst Development: Utilized for constructing chiral ligands and catalysts for asymmetric synthesis, leveraging its stereogenic center.
• Material Science Precursor: Potential use in the synthesis of specialized fluorinated polymers or surface-modifying agents.

Basic Information

Product Name	(2S)-2-Amino-3,3,3-trifluoropropan-1-ol hydrochloride
CAS No.	1255946-09-8
Molecular Formula	C3H7ClF3NO
Molecular Weight	177.54 g/mol
Synonyms	(S)-2-Amino-3,3,3-trifluoropropan-1-ol hydrochloride; L-2-Amino-3,3,3-trifluoropropanol hydrochloride; (2S)-2-Amino-3,3,3-trifluoropropyl alcohol hydrochloride; (S)-3,3,3-Trifluoroalaninol hydrochloride; (S)-1-Amino-2-trifluoromethylethanol hydrochloride; TFM Alaninol HCl (S-enantiomer); (S)-2-Trifluoromethyl-2-aminoethanol hydrochloride
EINECS	Contact for details

Quality Control

We supply (2S)-2-Amino-3,3,3-trifluoropropan-1-ol hydrochloride in high-purity grades suitable for research and GMP manufacturing. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as chiral purity, chemical purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.