Description

Methyl 3-Ethynyl-4-Methylbenzate is a high-purity, synthetically valuable organic intermediate featuring a terminal alkyne and a methyl ester functional group. This compound is critical for advanced organic synthesis, particularly in the construction of complex molecular architectures via cross-coupling and cycloaddition reactions. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of potential drug candidates, especially those requiring alkyne handles for click chemistry or Sonogashira coupling.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and plant growth regulators with tailored biological activity.
• Material Science: Serves as a monomer or precursor for advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Synthesis: Versatile reagent for constructing complex aromatic and heterocyclic compounds in academic and industrial R&D laboratories.
• Bioconjugation: The terminal alkyne group enables efficient labeling and modification of biomolecules for diagnostic and therapeutic applications.

Basic Information

Product Name	Methyl 3-Ethynyl-4-Methylbenzate
CAS No.	1255099-13-8
Molecular Formula	C11H10O2
Molecular Weight	174.20 g/mol
Synonyms	3-Ethynyl-4-methylbenzoic acid methyl ester; Methyl 3-ethynyl-p-toluate; Benzoic acid, 3-ethynyl-4-methyl-, methyl ester; 4-Methyl-3-((trimethylsilyl)ethynyl)benzoic acid methyl ester (precursor); Methyl 4-methyl-3-ethynylbenzoate
EINECS	Contact for details

Quality Control

Our Methyl 3-Ethynyl-4-Methylbenzate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity and identity confirmation. We provide detailed Certificates of Analysis (COA) with each shipment, which include data from HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.