Description

1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine is a versatile and high-value organoboron building block, specifically a pinacol boronate ester derivative of a substituted tetrahydropyridine. This compound is essential for modern synthetic chemistry, enabling efficient carbon-carbon bond formation through cross-coupling reactions like the Suzuki-Miyaura reaction. It is primarily sought after by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in creating complex nitrogen-containing heterocycles common in CNS and oncology drug candidates.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the tetrahydropyridine moiety imparts specific biological activity.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a critical coupling partner (boronic ester) to introduce the substituted tetrahydropyridine fragment into larger, more complex molecules under mild conditions.
• Material Science Research: Employed in the development of organic electronic materials, ligands for catalysts, and other functional organic compounds.
• Chemical Biology & Medicinal Chemistry: Utilized in the synthesis of molecular probes and tool compounds for target identification and validation in drug discovery programs.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds at various scales.

Basic Information

Product Name	1-Methyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1,2,3,6-Tetrahydropyridine
CAS No.	1254982-25-6
Molecular Formula	C16H28BNO2
Molecular Weight	277.21 g/mol
Synonyms	1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine; 1-Methyl-5-(pinacolatoboryl)-1,2,3,6-tetrahydropyridine; 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydro-pyridine; 1-Methyl-5-(pinacol boronate)-1,2,3,6-tetrahydropyridine; N-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridine; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-methyl-1,2,3,6-tetrahydropyridine
EINECS	Contact for details

Quality Control

Our 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid or crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.