Description

6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Imidazo[4,5-B]Pyridine is a high-purity, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex heterocyclic molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs) and drug candidates.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing carbon-carbon bonds in the synthesis of complex heterocyclic scaffolds for drug discovery.
• Pharmaceutical Intermediate: Serves as a versatile building block in the research and development of new therapeutic agents, particularly in oncology and CNS drug pipelines.
• Chemical Biology Probes: Used in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.
• Agrochemical Research: Employed in the discovery and synthesis of novel active ingredients for crop protection products.
• Material Science: A precursor for creating organic electronic materials and functional polymers requiring specific boron-containing motifs.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical and biotech clients with custom synthesis projects.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Imidazo[4,5-B]Pyridine
CAS No.	1254697-46-5
Molecular Formula	C14H18BN3O2
Molecular Weight	271.13 g/mol
Synonyms	1H-Imidazo[4,5-b]pyridine, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazo[4,5-b]pyridine; 6-(Pinacolatoboryl)-1H-imidazo[4,5-b]pyridine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[4,5-b]pyridine; 6-Boronic acid pinacol ester-1H-imidazo[4,5-b]pyridine
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Imidazo[4,5-B]Pyridine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.