Description

4-((1,4,8,11-Tetraazacyclotetradecan-1-Yl)Methyl)Benzaldehyde Trihydrochloride is a high-purity, functionalized macrocyclic ligand derivative, essential for advanced coordination chemistry and bioconjugation research. Its core value lies in its ability to chelate metal ions with high affinity and stability, serving as a critical precursor for synthesizing sophisticated diagnostic and therapeutic agents. This compound is primarily needed by researchers and manufacturers in the pharmaceutical, radiopharmaceutical, and biomedical imaging sectors, where precise molecular targeting and labeling are paramount.

Application

• Radiopharmaceutical Precursor: Key intermediate in the synthesis of chelating agents for labeling antibodies, peptides, and small molecules with diagnostic (e.g., 68Ga, 64Cu) or therapeutic (e.g., 177Lu, 225Ac) radioisotopes.
• MRI Contrast Agent Development: Used to create gadolinium(III) or other lanthanide-based complexes for magnetic resonance imaging (MRI) contrast enhancement.
• Catalyst Ligand Synthesis: Serves as a sophisticated ligand scaffold for designing homogeneous catalysts used in specialized organic transformations.
• Bioconjugation & Protein Labeling: The aldehyde functional group enables site-specific conjugation to amines via Schiff base formation, useful for attaching probes, drugs, or metals to biomolecules.
• Chemical Biology Research: A valuable tool for studying metal ion transport, enzyme inhibition, and cellular imaging in academic and industrial R&D settings.
• Sensor & Diagnostic Kit Component: Incorporated into the design of fluorescent or colorimetric sensors for detecting specific metal ions or biological analytes.

Basic Information

Product Name	4-((1,4,8,11-Tetraazacyclotetradecan-1-Yl)Methyl)Benzaldehyde Trihydrochloride
CAS No.	1254176-45-8
Molecular Formula	C20H35Cl3N4O
Molecular Weight	453.87 g/mol
Synonyms	4-((Cyclam-1-yl)methyl)benzaldehyde trihydrochloride; 4-(1,4,8,11-Tetraazacyclotetradecan-1-ylmethyl)benzaldehyde trihydrochloride; 4-Formylbenzyl-cyclam trihydrochloride; 1,4,8,11-Tetraazacyclotetradecane-1-(4-formylbenzyl) trihydrochloride; TETA-Benzaldehyde trihydrochloride; p-((Cyclam-1-yl)methyl)benzaldehyde trihydrochloride; Cyclam-CHO·3HCl
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and pharmaceutical development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and consistency. Certificates of Analysis (COA) detailing specific results for assay, impurity profile, and residual solvents are available upon request. We adhere to a quality management system to support applications requiring reliable and traceable materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere if specified and after each use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.