Description

1-(3,5-Dichlorophenyl)-2,2-Difluoroethanone is a high-purity, specialized organic building block featuring a difluoroacetyl group attached to a symmetrically substituted dichlorophenyl ring. This compound is valued for its role as a critical intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists working on novel active ingredients, where its unique halogenated structure enables the introduction of key pharmacophores.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting enzyme inhibition.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the dichlorophenyl motif for biological activity.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers or ligands used in advanced polymeric materials or catalysts.
• Organic Synthesis Building Block: Employed in academic and industrial laboratories for constructing complex aromatic ketones and heterocyclic compounds.
• Fluorine Chemistry Studies: Utilized as a model compound in research exploring the effects of gem-difluoro groups on reactivity and physical properties.

Basic Information

Product Name	1-(3,5-Dichlorophenyl)-2,2-Difluoroethanone
CAS No.	1253787-55-1
Molecular Formula	C8H4Cl2F2O
Molecular Weight	225.02 g/mol
Synonyms	3,5-Dichloro-α,α-difluoroacetophenone; 2,2-Difluoro-1-(3,5-dichlorophenyl)ethanone; 1-(3,5-Dichlorophenyl)-2,2-difluoroethan-1-one; 3',5'-Dichloro-2,2-difluoroacetophenone; (3,5-Dichlorophenyl)difluoromethyl ketone; DFDA; 1253787-55-1 (CAS)
EINECS	Contact for details

Quality Control

Our 1-(3,5-Dichlorophenyl)-2,2-Difluoroethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.