Description

2-(2,3-Dihydro-1H-Inden-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient and selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to introduce the indane moiety into target molecules. The CAS number for this compound is 1252793-57-9.

Application

This versatile boronic ester is a key intermediate in several high-value chemical synthesis pathways. Its primary applications include:

• Suzuki-Miyaura Cross-Coupling Reactions: As a pivotal reagent for forming carbon-carbon bonds to construct biaryl and heterobiaryl systems prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Synthesis of drug candidates targeting central nervous system (CNS) disorders, cardiovascular diseases, and inflammation, where the indane scaffold is pharmacologically relevant.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides that require specific stereochemistry and functional group compatibility.
• Material Science Research: Precursor for organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where conjugated systems are crucial.
• Ligand and Catalyst Development: Used to create novel chiral or functionalized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Chemical Biology Probes: Tagging and modifying biomolecules for study due to its selective reactivity under mild conditions.

Basic Information

Product Name	2-(2,3-Dihydro-1H-Inden-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1252793-57-9
Molecular Formula	C₁₅H₂₁BO₂
Molecular Weight	244.14 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-indene; 2,3-Dihydro-1H-indene-4-boronic acid pinacol ester; 4-Indanylboronic acid pinacol ester; 4-(Pinacolatoboryl)-2,3-dihydro-1H-indene; 1H-Indene, 2,3-dihydro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 1252793-57-9; Indan-4-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2,3-Dihydro-1H-Inden-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We can support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (argon or nitrogen) in a freezer (-20°C to -10°C) for long-term stability. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area Percent)
Purity (NMR)	≥95.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.