Description

1-(4-Bromo-Thiophen-2-Yl)-2,2,2-Trifluoro-Ethanone is a high-purity, specialized organic building block featuring a brominated thiophene core and a reactive trifluoroacetyl group. This compound is valued for its role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the life sciences and specialty chemical sectors for constructing novel heterocyclic frameworks.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing thiophene or fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, where the bromine atom allows for further functionalization via cross-coupling reactions.
• Material Science Precursor: Serves as a monomer or precursor in the development of advanced organic electronic materials, such as conductive polymers and organic semiconductors.
• Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: The trifluoroacetyl group is a valuable synthon for introducing fluorine atoms into target molecules, a common strategy in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Item	Details
Product Name	1-(4-Bromo-Thiophen-2-Yl)-2,2,2-Trifluoro-Ethanone
CAS No.	1252046-14-2
Molecular Formula	C6H2BrF3OS
Molecular Weight	258.04 g/mol
Synonyms	4-Bromo-2-(trifluoroacetyl)thiophene; 2,2,2-Trifluoro-1-(4-bromo-2-thienyl)ethanone; 1-(4-Bromothiophen-2-yl)-2,2,2-trifluoroethanone; 4-Bromo-α,α,α-trifluoro-2-thiopheneacetone; 4-Bromo-2-thenoyltrifluoroacetone; 4-Bromo-2-trifluoroacetylthiophene; BTTA; 4-Bromo-2-(trifluoroacetyl)thiophene
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-Thiophen-2-Yl)-2,2,2-Trifluoro-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.