Description

1,3,2-Dioxaborolane, 2-[3,5-Difluoro-4-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl- is a high-value, organoboron building block featuring a pinacol boronic ester group on a difluorinated and trifluoromethylated aromatic core. This compound is essential for modern synthetic chemistry, enabling the precise construction of complex molecules through reliable cross-coupling reactions. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated drug candidates, including kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used to introduce the difluoro(trifluoromethyl)phenyl moiety into novel herbicides, fungicides, and pesticides to enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a monomer or building block for creating advanced organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport layers.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis, particularly where electron-deficient arene systems are required.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes for studying biological processes and protein-ligand interactions.
• Fluorine Chemistry: A valuable reagent for exploring new methodologies in fluoroorganic chemistry and introducing specific fluorine patterns into target molecules.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[3,5-Difluoro-4-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	1251844-06-0
Molecular Formula	C13H14B1F5O2
Molecular Weight	308.06 g/mol
Synonyms	(3,5-Difluoro-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; 2-(3,5-Difluoro-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-[3,5-difluoro-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; 3,5-Difluoro-4-(trifluoromethyl)benzeneboronic acid pinacol ester; Pinacol (3,5-Difluoro-4-(trifluoromethyl)phenyl)boronate
EINECS	Contact for details

Quality Control

Every batch of our 1,3,2-Dioxaborolane, 2-[3,5-Difluoro-4-(Trifluoromethyl)Phenyl]-4,4,5,5-Tetramethyl- is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to ensure material consistency and support your regulatory filings. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container for use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.