Description

tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclohex-3-Enylcarbamate is a high-value, protected amine-containing boronic ester building block, essential for modern synthetic chemistry. Its core value lies in enabling efficient, selective cross-coupling reactions, particularly Suzuki-Miyaura couplings, to construct complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronate ester reagent for palladium-catalyzed carbon-carbon bond formation with aryl or vinyl halides.
• Peptidomimetic & PROTAC Synthesis: Used to introduce functionalized cyclohexene scaffolds into complex molecules like proteolysis-targeting chimeras (PROTACs) and peptide analogs.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides requiring specific stereochemistry and functional group arrays.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of advanced polymers and organic electronic materials.
• Chemical Biology Probe Development: Utilized to create tagged or modified small molecules for studying biological pathways and protein function.

Basic Information

Product Name	tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclohex-3-Enylcarbamate
CAS No.	1251732-64-5
Molecular Formula	C₁₇H₃₀BNO₄
Molecular Weight	323.24 g/mol
Synonyms	4-((tert-Butoxycarbonyl)amino)cyclohex-3-ene-1-boronic acid pinacol ester; N-Boc-4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexen-1-amine; tert-Butyl (4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)cyclohex-3-en-1-yl)carbamate; 4-N-Boc-3-cyclohexenylboronic acid pinacol ester; 3-Cyclohexene-1-boronic acid, 4-[[(1,1-dimethylethoxy)carbonyl]amino]-, 1,1-dimethylethyl ester, cyclic pinanediol ester; Boc-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexen-1-amine; (1,1-Dimethylethyl) N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyclohexen-1-yl]carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Cyclohex-3-Enylcarbamate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural integrity suitable for sensitive cross-coupling reactions. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.