Description

n-Cbz-1,2,3,6-Tetrahydropyridin-4-Ylboronic Acid CAS NO 1251537-33-3 is a high-purity, advanced pharmaceutical intermediate featuring a protected tetrahydropyridine scaffold with a boronic acid functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of complex, nitrogen-containing heterocycles. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the discovery and development of new therapeutic agents.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing carbon-carbon bonds in the synthesis of novel drug candidates, particularly those containing complex piperidine and tetrahydropyridine motifs.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry & Drug Discovery: Enables rapid library synthesis for structure-activity relationship (SAR) studies and high-throughput screening in early-stage R&D programs.
• Process Chemistry & Scale-Up: Used in the development and optimization of robust, scalable synthetic routes for clinical and commercial API manufacturing.
• Bioconjugation & Chemical Biology: Potential utility in creating bioconjugates or chemical probes for biological target identification and validation.

Basic Information

Product Name	n-Cbz-1,2,3,6-Tetrahydropyridin-4-Ylboronic Acid
CAS No.	1251537-33-3
Molecular Formula	C₁₃H₁₆BNO₄
Molecular Weight	261.08 g/mol
Synonyms	1,2,3,6-Tetrahydro-4-pyridineboronic acid, N-Cbz-protected; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,6-tetrahydropyridine-1-carboxylic acid benzyl ester; Benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1(2H)-pyridinecarboxylate; N-Cbz-4-Borono-1,2,3,6-tetrahydropyridine; Carbobenzyloxy-1,2,3,6-tetrahydropyridin-4-ylboronic acid; 1-Cbz-1,2,3,6-Tetrahydropyridin-4-ylboronic Acid
EINECS	Contact for details

Quality Control

Our n-Cbz-1,2,3,6-Tetrahydropyridin-4-Ylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere. This material is hygroscopic (moisture-sensitive) and must be handled in a dry environment to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.