Description

4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isothiazole is a high-value boronic ester derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise and reliable synthetic intermediates for drug discovery and specialty chemical production.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of heterocyclic compounds with potential therapeutic activity.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides that require the isothiazole moiety.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials through cross-coupling reactions.
• Chemical Research & Development: A versatile reagent in academic and industrial R&D labs for constructing complex molecular architectures via palladium-catalyzed coupling.
• Ligand and Catalyst Development: Useful for synthesizing novel bidentate or tridentate ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isothiazole
CAS No.	1251459-71-8
Molecular Formula	C9H14BNO2S
Molecular Weight	211.09 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-thiazole; 4-Isothiazoleboronic acid pinacol ester; 4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)isothiazole; Isothiazole-4-boronic acid pinacol ester; 4-Boronophenyl isothiazole pinacol ester; 4-(Pinacolatoboryl)isothiazole; 4-Isothiazolylboronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Isothiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.