Description

3,3-Difluoro-1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester is a high-value, advanced pharmaceutical intermediate featuring a unique spirocyclic and diaza scaffold. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel drug candidates targeting central nervous system (CNS) disorders and other therapeutic areas. Its structural complexity, including the difluoro and tert-butyl ester protecting group, makes it an essential building block for pharmaceutical companies and contract research organizations (CROs) engaged in modern drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical development.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery, especially for CNS targets.
• Proteolysis Targeting Chimera (PROTAC) Development: The spirocyclic diaza structure can serve as a component in the design of linkers or warheads for targeted protein degradation molecules.
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Scale-Up: Serves as a starting material for contract manufacturing organizations (CMOs) performing custom synthesis and process development.
• Academic Research: Employed in university and institutional labs for advanced organic synthesis methodology and novel heterocyclic chemistry research.

Basic Information

Product Name	3,3-Difluoro-1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester
CAS No.	1250999-05-3
Molecular Formula	C13H22F2N2O2
Molecular Weight	276.33 g/mol
Synonyms	tert-Butyl 3,3-difluoro-1,8-diazaspiro[4.5]decane-8-carboxylate; 1,8-Diaza-spiro[4.5]decane-8-carboxylic acid, 3,3-difluoro-, 1,1-dimethylethyl ester; 8-Boc-3,3-difluoro-1,8-diazaspiro[4.5]decane; 3,3-Difluoro-1,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester; 3,3-Difluoro-8-(tert-butoxycarbonyl)-1,8-diazaspiro[4.5]decane
EINECS	Contact for details

Quality Control

Our 3,3-Difluoro-1,8-Diaza-Spiro[4.5]Decane-8-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support our clients with full traceability and documentation to meet the stringent requirements of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.