Description

2’,6’-Difluoro-2-Hydroxyacetophenone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms and the reactive ketone and phenolic hydroxyl groups, enabling precise molecular modifications. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly in kinase inhibitor and anti-inflammatory research.
• Agrochemical Synthesis: Used in developing novel herbicides and pesticides where the difluoro-hydroxyacetophenone scaffold imparts desirable biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a versatile starting material for creating chelating ligands and organocatalysts in asymmetric synthesis.
• Material Science Research: Employed in the development of specialty monomers for advanced polymers with tailored optical or electronic properties.
• Fluorine Chemistry Studies: An important substrate for investigating new fluorination reactions and studying structure-activity relationships (SAR).

Basic Information

Product Name	2’,6’-Difluoro-2-Hydroxyacetophenone
CAS No.	1250656-10-0
Molecular Formula	C8H6F2O2
Molecular Weight	172.13 g/mol
Synonyms	1-(2,6-Difluorophenyl)-2-hydroxyethan-1-one; 2',6'-Difluoro-2-hydroxyacetophenone; 2-Hydroxy-1-(2,6-difluorophenyl)ethanone; 2-Acetyl-3,5-difluorophenol; (2,6-Difluorophenyl)(hydroxy)methyl ketone
EINECS	Contact for details

Quality Control

Our 2’,6’-Difluoro-2-Hydroxyacetophenone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive). Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.