Description

(3,3-Difluorocyclobutyl)-n-Methylmethanamine Hydrochloride is a high-purity, advanced pharmaceutical intermediate featuring a unique cyclobutyl scaffold with strategic fluorine substitution. This compound is critical for medicinal chemistry research and development, offering a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating new drug candidates and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disorder targets.
• Medicinal Chemistry Building Block: Used in structure-activity relationship (SAR) studies and lead optimization due to its constrained cyclobutane ring and fluorine atoms, which can modulate potency, metabolic stability, and lipophilicity.
• Agrochemical Research: Serves as a precursor in the synthesis of novel herbicides, fungicides, and insecticides, leveraging the physicochemical properties imparted by the difluorocyclobutyl group.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis or as a component in organocatalysts.
• Chemical Biology Probe Synthesis: Utilized to create tool compounds for investigating biological pathways and protein function.
• Custom Synthesis and Contract Manufacturing: Supplied for bespoke synthesis projects requiring high-quality, complex amine derivatives.

Basic Information

Product Name	(3,3-Difluorocyclobutyl)-n-Methylmethanamine Hydrochloride
CAS No.	1250444-03-1
Molecular Formula	C7H14ClF2N
Molecular Weight	185.64 g/mol
Synonyms	1-[(3,3-Difluorocyclobutyl)methyl]-N-methylmethanamine hydrochloride; N-Methyl-1-(3,3-difluorocyclobutyl)methanamine hydrochloride; (3,3-Difluorocyclobutyl)methyl(methyl)amine hydrochloride; 1-(3,3-Difluorocyclobutyl)-N-methylmethanamine HCl; N-[(3,3-Difluorocyclobutyl)methyl]-N-methylamine hydrochloride; 3,3-Difluorocyclobutanemethanamine, N-methyl-, hydrochloride
EINECS	Contact for details

Quality Control

Our (3,3-Difluorocyclobutyl)-n-Methylmethanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and industry best practices for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.