Description

1-[5-Chloro-2-(Difluoromethoxy)Phenyl]Ethan-1-One is a specialized aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in its unique molecular scaffold, which incorporates both chloro and difluoromethoxy substituents, enabling the construction of complex molecules with tailored properties. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-inflammatory applications.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the difluoromethoxy group.
• Material Science Research: Used in the development of specialty polymers and advanced organic materials where the introduction of fluorine atoms can modify thermal stability and solubility.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing complex chelating ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific fluorinated aromatic ketone.

Basic Information

Product Name	1-[5-Chloro-2-(Difluoromethoxy)Phenyl]Ethan-1-One
CAS No.	1250157-06-2
Molecular Formula	C9H7ClF2O2
Molecular Weight	220.60 g/mol
Synonyms	5'-Chloro-2'-(difluoromethoxy)acetophenone; 1-(5-Chloro-2-(difluoromethoxy)phenyl)ethanone; 2-Acetyl-4-chloro-1-(difluoromethoxy)benzene; 5-Chloro-2-(difluoromethoxy)acetophenone; 1-Acetyl-5-chloro-2-(difluoromethoxy)benzene; 2-(Difluoromethoxy)-5-chloroacetophenone; Ethanone, 1-[5-chloro-2-(difluoromethoxy)phenyl]-
EINECS	Contact for details

Quality Control

Our production of 1-[5-Chloro-2-(Difluoromethoxy)Phenyl]Ethan-1-One adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure consistency and reliability for your critical synthesis workflows. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.