Description

5-(3-Fluoro-Phenyl)-3-Prop-2-Ynyl-3H-Imidazol-4-Ylamine is a high-purity, advanced pharmaceutical intermediate characterized by its unique imidazole core functionalized with a fluoro-phenyl group and a propargyl side chain. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of targeted small molecule therapeutics. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel drug candidates for oncology, neurology, and inflammatory diseases.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates targeting protein kinases and other enzymatic pathways.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Bioconjugation & Probe Development: The alkyne (prop-2-ynyl) group enables click chemistry reactions for labeling, imaging, and proteomics applications.
• Chemical Biology: Serves as a precursor for developing enzyme inhibitors and molecular probes to study biological mechanisms.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis to create complex heterocyclic compounds for high-value applications.

Basic Information

Product Name	5-(3-Fluoro-Phenyl)-3-Prop-2-Ynyl-3H-Imidazol-4-Ylamine
CAS No.	1247227-07-1
Molecular Formula	C12H10FN3
Molecular Weight	215.23 g/mol
Synonyms	5-(3-Fluorophenyl)-3-(prop-2-yn-1-yl)-3H-imidazol-4-amine; 4-Amino-5-(3-fluorophenyl)-3-(2-propynyl)-3H-imidazole; 3-(Prop-2-yn-1-yl)-5-(3-fluorophenyl)-1H-imidazol-4-amine; 1247227-07-1; 5-(3-Fluorophenyl)-3-prop-2-ynyl-1H-imidazol-4-amine; 5-(3-Fluorophenyl)-3-(prop-2-ynyl)-1H-imidazol-4-amine
EINECS	Contact for details

Quality Control

Our 5-(3-Fluoro-Phenyl)-3-Prop-2-Ynyl-3H-Imidazol-4-Ylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.