Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaboratophenyl)-Methyl Triphenylphosphonium Bromide is a high-value, multifunctional organoboron reagent and Wittig salt. This compound is critical for advanced organic synthesis, serving as a versatile building block for constructing complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional polymers.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a key boronic ester precursor for forming carbon-carbon bonds in medicinal chemistry and material science.
• Wittig Olefination: Functions as a stabilized ylide reagent for the synthesis of alkenes and conjugated systems with high stereoselectivity.
• Pharmaceutical Intermediate: Used in the synthesis of complex drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Employed in creating novel active ingredients for crop protection with specific functional groups.
• Liquid Crystal & OLED Material Development: Serves as a building block for creating advanced organic electronic materials and display components.
• Polymer & Resin Modification: Used to introduce boronate or phosphonium functionalities into polymer backbones for specialty applications.
• Chemical Biology Probes: Utilized in the development of tagged molecules for studying biological pathways and protein interactions.
• Catalyst Ligand Synthesis: Acts as a precursor for sophisticated phosphine-based ligands used in homogeneous catalysis.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaboratophenyl)-Methyl Triphenylphosphonium Bromide
CAS No.	1247025-85-9
Molecular Formula	C31H35BBrO2P
Molecular Weight	576.30 g/mol
Synonyms	[4-(Bromomethyl)phenyl]boronic acid pinacol ester triphenylphosphonium bromide; (4-Bromomethylphenyl)boronic acid pinacol ester triphenylphosphonium salt; 4-(Bromomethyl)benzeneboronic acid pinacol ester triphenylphosphonium bromide; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyltriphenylphosphonium bromide; [3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyltriphenylphosphonium bromide; Wittig-Boronate Reagent; CAS 1247025-85-9
EINECS	Contact for details

Quality Control

Our production of 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaboratophenyl)-Methyl Triphenylphosphonium Bromide adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ³¹P, ¹¹B), HPLC, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with full traceability are provided for all shipments, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for prolonged operations to maintain stability and purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.