Description

4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine is a high-value, advanced pharmaceutical intermediate featuring a piperidine core linked to a pinacol boronate ester. This compound is essential for modern synthetic chemistry, particularly in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex carbon-carbon bonds. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a functionalized piperidine moiety.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables palladium-catalyzed coupling with aryl or vinyl halides to create biaryl structures, a cornerstone reaction in medicinal chemistry and material science.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate complex aromatic and heterocyclic systems.
• Organic Electronic Materials: Serves as a precursor for the development of organic light-emitting diodes (OLEDs), semiconductors, and other advanced functional materials.
• Chemical Biology & Proteomics: Can be employed as a molecular probe or linker in bioconjugation chemistry and the development of chemical tools for biological research.
• Academic & Industrial R&D: A versatile reagent for method development and exploratory synthesis in university and corporate research laboratories.

Basic Information

Product Name	4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine
CAS No.	1247000-93-6
Molecular Formula	C17H26BNO2
Molecular Weight	287.21 g/mol
Synonyms	4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)piperidine; 4-(4-Pinacolatoboranephenyl)piperidine; 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]piperidine; 4-(4-(Pinacolboron)phenyl)piperidine; 4-Piperidin-4-ylphenylboronic acid pinacol ester; 4-(Piperidin-4-yl)phenylboronic acid pinacol ester; 4-(4-Piperidylphenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 4-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Piperidine is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Recommended storage temperature is 2-8°C for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.