Description

1-(2-Hydroxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Ethanone is a high-value boronic ester derivative, serving as a critical synthetic intermediate in modern organic chemistry. Its core value lies in its dual functionality, combining a protected boronic acid group with a phenolic ketone, enabling precise cross-coupling and subsequent functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors who require reliable, high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators that incorporate aryl-boronate motifs.
• Organic Light-Emitting Diodes (OLEDs): Serves as a precursor for electron-transport materials and host molecules in the fabrication of advanced display and lighting technologies.
• Ligand and Catalyst Development: Employed in the creation of novel bidentate ligands and organometallic catalysts for asymmetric synthesis and polymerization processes.
• Polymer and Material Science: Acts as a monomer or functionalization agent for creating specialty polymers with tailored thermal, optical, or mechanical properties.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme activity and protein-protein interactions.

Basic Information

Product Name	1-(2-Hydroxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Ethanone
CAS No.	1246560-24-6
Molecular Formula	C14H19BO4
Molecular Weight	262.11 g/mol
Synonyms	2'-Hydroxy-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)acetophenone; 1-(2-Hydroxy-4-(pinacolatoboryl)phenyl)ethanone; 4-Acetyl-3-hydroxyphenylboronic acid pinacol ester; 4-Acetyl-3-hydroxybenzeneboronic acid pinacol ester; 2-Hydroxy-4-(pinacolatoboryl)acetophenone; 4-(Pinacolatoboryl)-2-hydroxyacetophenone; 1246560-24-6 (CAS)
EINECS	Contact for details

Quality Control

Our 1-(2-Hydroxy-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.