Description

2-Amino-3-Cyanopyridine-5-Boronic Acid Pinacol Ester is a high-value, multi-functional boronic ester building block crucial for modern synthetic chemistry. Its core value lies in enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, to construct complex heterocyclic scaffolds. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides with specific modes of action.
• Material Science: Serves as a precursor for creating functionalized polymers, organic electronic materials, and metal-organic frameworks (MOFs).
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and activity-based protein profiling (ABPP) reagents.
• Suzuki-Miyaura Cross-Coupling: The primary application is as a versatile coupling partner with aryl/heteroaryl halides to form biaryl and heterobiaryl structures.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening (HTS) in medicinal chemistry.

Basic Information

Product Name	2-Amino-3-Cyanopyridine-5-Boronic Acid Pinacol Ester
CAS No.	1246372-66-6
Molecular Formula	C13H16BN3O2
Molecular Weight	257.10 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-cyanopyridin-2-amine; 2-Amino-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinonitrile; 2-Amino-3-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 2-Amino-5-(pinacolatoboryl)-3-cyanopyridine; 2-Amino-3-cyanopyridine-5-boronic acid pinacol ester; 3-Cyano-2-amino-5-pyridineboronic acid pinacol ester; 5-Boronic acid pinacol ester-2-amino-3-cyanopyridine
EINECS	Contact for details

Quality Control

Our 2-Amino-3-Cyanopyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production. We employ advanced analytical techniques including HPLC, NMR, and LC-MS for comprehensive characterization. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.