Description

3-Hydroxypyridine-2-Boronic Acid is a versatile heterocyclic boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a boronic acid group for Suzuki-Miyaura cross-coupling reactions with a hydroxypyridine moiety that can act as a ligand or a directing group. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules and developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system and anti-infectives.
• Suzuki-Miyaura Cross-Coupling: The boronic acid group enables efficient carbon-carbon bond formation, crucial for creating biaryl and heterobiaryl structures in medicinal chemistry.
• Ligand in Catalysis: The hydroxypyridine unit can coordinate to metal centers, making it useful in designing catalysts for asymmetric synthesis and other transition metal-catalyzed reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require complex heterocyclic cores.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of organic electronic materials, such as polymers for OLEDs or sensors.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme function or protein-protein interactions due to its ability to form stable complexes.

Basic Information

Item	Detail
Product Name	3-Hydroxypyridine-2-Boronic Acid
CAS No.	1245942-28-2
Molecular Formula	C5H6BNO3
Molecular Weight	138.92 g/mol
Synonyms	2-Borono-3-hydroxypyridine; 3-Hydroxy-2-pyridineboronic acid; (3-Hydroxypyridin-2-yl)boronic acid; 3-Hydroxypyridine-2-boronic acid pinacol ester (protected form); 2-Pyridineboronic acid, 3-hydroxy-; 3-Hydroxy-2-pyridinylboronic acid; 1245942-28-2
EINECS	Contact for details

Quality Control

Our 3-Hydroxypyridine-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.