Description

tert-Butyl 1-(4-Formylphenyl)-1-Oxo-5,8,11,14,17,20,23,26,29,32,35-Undecaoxa-2-Azaheptatriacontan-37-Ylcarbamate is a specialized bifunctional PEG linker featuring a reactive aldehyde group and a tert-butyloxycarbonyl (Boc)-protected amine. This compound matters for its role as a critical building block in bioconjugation and pharmaceutical development, enabling the precise, site-specific attachment of biomolecules, drugs, or probes. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for creating advanced drug delivery systems, antibody-drug conjugates (ADCs), and functionalized nanomaterials.

Application

• Antibody-Drug Conjugate (ADC) Development: Serves as a heterobifunctional crosslinker for coupling cytotoxic payloads to monoclonal antibodies via its aldehyde and protected amine functionalities.
• PEGylation Reagent: Used to introduce a long, hydrophilic polyethylene glycol (PEG) chain onto peptides, proteins, or small molecules to enhance solubility, stability, and circulation time.
• Bioconjugation and Protein Labeling: Facilitates the site-specific modification of proteins, enzymes, or other biomolecules for diagnostic assays, imaging probes, and biosensor development.
• Polymer Therapeutics and Drug Delivery Systems: Acts as a key intermediate in synthesizing smart polymer-drug conjugates and targeted nanocarriers.
• Surface Functionalization: Employed to modify nanoparticles, quantum dots, or solid supports with reactive groups for subsequent immobilization of ligands or capture molecules.
• Solid-Phase Peptide Synthesis (SPPS): Can be used as a protected linker for the synthesis of complex peptide-PEG conjugates.

Basic Information

Product Name	tert-Butyl 1-(4-Formylphenyl)-1-Oxo-5,8,11,14,17,20,23,26,29,32,35-Undecaoxa-2-Azaheptatriacontan-37-Ylcarbamate
CAS No.	1245813-70-0
Molecular Formula	C45H79NO16
Molecular Weight	914.1 g/mol
Synonyms	Boc-NH-PEG11-CHO; 4-Formylbenzyl-PEG11-Boc amine; tert-Butyl (1-oxo-1-(4-formylphenyl)-5,8,11,14,17,20,23,26,29,32,35-undecaoxa-2-azaheptatriacontan-37-yl)carbamate; Boc-Amine-PEG11-Aldehyde; Aldehyde-PEG11-Boc; Heterobifunctional PEG linker, Boc-amine and aldehyde; 4-Formylbenzyl-PEG11-NHBoc; Boc-N-amido-PEG11-4-formylbenzyl
EINECS	Contact for details

Quality Control

Our tert-Butyl 1-(4-Formylphenyl)-1-Oxo-5,8,11,14,17,20,23,26,29,32,35-Undecaoxa-2-Azaheptatriacontan-37-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and structural integrity suitable for research and bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and hydrolysis. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.