Description

5-Bromo-2-(tert-Butyldimethylsilyl)-4-Methylthiazole is a high-value organosilicon-protected thiazole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in enabling precise, multi-step synthesis, particularly in the construction of complex heterocyclic scaffolds. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those containing functionalized thiazole cores.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science Research: Serves as a precursor for organic electronic materials and ligands for catalysis due to its silyl-protecting group and bromine functionality.
• Complex Molecule Construction: Facilitates cross-coupling reactions (e.g., Suzuki, Stille) and further functionalization in multi-step synthetic routes.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and heterocyclic chemistry.

Basic Information

Product Name	5-Bromo-2-(tert-Butyldimethylsilyl)-4-Methylthiazole
CAS No.	1245782-59-5
Molecular Formula	C₁₀H₁₈BrNSSi
Molecular Weight	292.31 g/mol
Synonyms	4-Methyl-5-bromo-2-[(1,1-dimethylethyl)dimethylsilyl]thiazole; 2-(tert-Butyldimethylsilyl)-5-bromo-4-methylthiazole; 5-Bromo-4-methyl-2-((tert-butyldimethylsilyl)thiazole; TBDMS-Protected 5-Bromo-4-methylthiazole; 5-Bromo-2-(TBDMS)-4-methylthiazole; 1245782-59-5; 5-Br-2-TBDMS-4-Me-thiazole
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-(tert-Butyldimethylsilyl)-4-Methylthiazole is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere if possible. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.