Description

N,n-Diethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide is a high-purity boronic ester derivative of nicotinamide, serving as a critical building block in modern synthetic chemistry. Its value lies in enabling efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and central nervous system (CNS) research.
• Agrochemical Synthesis: Used in the development of novel pesticides and herbicides through palladium-catalyzed cross-coupling reactions.
• Material Science Research: Serves as a precursor for creating organic electronic materials, including polymers and small molecules for OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Utilized in the synthesis of molecular probes and bioconjugation reagents for studying biological processes.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and catalysis studies.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	N,n-Diethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide
CAS No.	1245728-86-2
Molecular Formula	C18H29BN2O3
Molecular Weight	332.25 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N,N-diethylnicotinamide; N,N-Diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-carboxamide; 3-Pyridinecarboxamide, N,N-diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)nicotinamide diethyl derivative; Diethyl 5-(pinacolatoboryl)nicotinamide; Pinacol 5-(N,N-diethylcarbamoyl)pyridin-3-ylboronate
EINECS	Contact for details

Quality Control

Our N,n-Diethyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Nicotinamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We support cGMP and ISO standards for pharmaceutical and research applications, ensuring traceability and consistency for critical synthetic workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.