Description

Ethyl2,2-Difluoro-2-(Thiophen-3-Yl)Acetate is a high-purity fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of fluorine atoms is crucial for modulating biological activity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate difluoroacetate motifs into complex molecular architectures.

Application

• As a critical fluorinated synthon in the research and development of new pharmaceutical candidates.
• Key intermediate in the synthesis of agrochemicals, such as herbicides and fungicides, to enhance efficacy and environmental profile.
• Building block for liquid crystal materials and other advanced electronic chemicals.
• Used in organic light-emitting diode (OLED) material research.
• Intermediate for the preparation of complex ligands and catalysts used in asymmetric synthesis.
• Starting material in academic and industrial research exploring novel fluorination methodologies and reaction pathways.

Basic Information

Product Name	Ethyl2,2-Difluoro-2-(Thiophen-3-Yl)Acetate
CAS No.	1245643-36-0
Molecular Formula	C8H8F2O2S
Molecular Weight	206.21 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-thienyl)acetate; 2,2-Difluoro-2-(thiophen-3-yl)acetic Acid Ethyl Ester; 3-Thiopheneacetic acid, 2,2-difluoro-, ethyl ester; Ethyl α,α-Difluoro-3-thiopheneacetate; 1245643-36-0; Ethyl 2,2-difluoro-2-(thiophen-3-yl)acetate
EINECS	Contact for details

Quality Control

Our Ethyl2,2-Difluoro-2-(Thiophen-3-Yl)Acetate is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.