Description

2-Cyclopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is a high-purity boronic ester derivative, a crucial building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecules. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries, particularly in the development of novel active ingredients and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially in heterocyclic chemistry for CNS, antiviral, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides containing thiazole and cyclopropyl motifs.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugation reagents for target identification and labeling.
• Academic & R&D Laboratories: A versatile reagent for methodological development in cross-coupling chemistry and heterocycle functionalization.
• Custom Synthesis & Contract Manufacturing: A critical starting material for the bespoke production of complex, boronate-containing target molecules.

Basic Information

Product Name	2-Cyclopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole
CAS No.	1245524-04-2
Molecular Formula	C12H18BNO2S
Molecular Weight	251.15 g/mol
Synonyms	2-Cyclopropyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; 2-Cyclopropylthiazole-5-boronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopropyl-1,3-thiazole; 2-Cyclopropyl-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole; Thiazole-5-boronic acid, 2-cyclopropyl-, pinacol ester; 2-Cyclopropyl-5-(pinacolboron)thiazole; 2-Cyclopropyl-5-(pinacolatoboryl)thiazole; 2-Cyclopropylthiazol-5-ylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Cyclopropyl-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We adhere to cGMP principles for advanced intermediates to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon/nitrogen) for long-term storage or when opening the container to prevent hydrolysis of the boronic ester moiety.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.