Description

tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Ylcarbamate is a high-value organoboron building block, specifically a thiazole-containing boronic ester derivative. This compound is essential for modern synthetic chemistry, enabling the precise construction of complex molecules through cross-coupling reactions. It is primarily utilized by pharmaceutical and agrochemical research organizations for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing thiazole heterocycles for therapeutic applications.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boron reagent for forming carbon-carbon bonds, enabling the modular assembly of complex molecular architectures in drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that leverage the biological activity of the thiazole moiety.
• Material Science: Employed in the synthesis of organic electronic materials, such as semiconductors and light-emitting compounds, where precise molecular structure is paramount.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of molecular probes and inhibitors for target identification.

Basic Information

Product Name	tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Ylcarbamate
CAS No.	1245252-99-6
Molecular Formula	C₁₄H₂₃BN₂O₃S
Molecular Weight	310.22 g/mol
Synonyms	2-[[(1,1-Dimethylethoxy)carbonyl]amino]-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazol-2-amine, N-BOC-protected; tert-Butyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-thiazol-2-yl]carbamate; BOC-Thiazole-Boronic Acid Pinacol Ester; 2-(Boc-amino)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiazole
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiazol-2-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under inert atmosphere when appropriate for prolonged use to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.